Functional analysis of the escherichia coli hemolysin signal sequence by random oligonucleotide mutagenesis
The E. coli hemolysin is an RTX toxin that is secreted by an ATP-binding cassette transporter complex consisting of HlyB, HlyD, and TolC. Translocation of this protein is dependent on a C-terminal signal sequence located within the last 60 amino acids. Previous studies demonstrated that the signa...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/9237 |