Analysis of the neuroprotective function and the N-glycosylation progranulin (PGRN)
Recent studies have identified null mutations in the progranulin (PGRIV) gene as the cause of pathogenesis of Frontotemporal lobe dementia (FTLD). It was found that PGRN protein levels are reduced in patients due to haploinsufficiency. However, the functions of progranulin in the central nervous...
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| Language: | English |
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University of British Columbia
2009
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| Online Access: | http://hdl.handle.net/2429/7726 |