Bioactive marine natural products : isolation, structure elucidation and synthesis of pharmacophore analogues

Bioassay-guided fractionation of the marine sponge Spongia irregularis led to the isolation of a new sulfated sesterterpenoid, irregularasulfate (2.16), along with two known sulfated sesterterpenoids, halisulfate 7 (2.14) and hipposulfate C (2.15). All three compounds (2.14-2.16) inhibit the relate...

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Bibliographic Details
Main Author: Carr, Gavin
Language:English
Published: University of British Columbia 2010
Online Access:http://hdl.handle.net/2429/23166