The role of the low-density lipoprotein receptor family on Cyclosporine A uptake and toxicity in renal cells

Background: Cyclosporine A (CsA) is an effective immunosuppressant drug to treat patients who have undergone transplantation or to treat autoimmune diseases. However, the drug is limited by its narrow therapeutic index and usually becomes discontinued due to high nephrotoxicity. CsA is known to h...

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Bibliographic Details
Main Author: Chung, Nancy S.C.
Language:English
Published: 2009
Online Access:http://hdl.handle.net/2429/15474