The use of inhibitors to stabilize folded conformations of enzymes
Tay Sachs and Gaucher diseases are lysosomal storage disorders that are caused by deficiencies in the lysosomal enzymes β-hexosaminidase A and glucocerebrosidase, respectively. The glycolipid substrates of deficient β-hexosaminidase A and glucocerebrosidase accumulate in lysosomal neurons, result...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/15209 |