Role of endoplasmic reticulum calcium stores in beta-cell ER stress and lipotoxicity
There are strong links between obesity, elevated free fatty acids, and type 2 diabetes. Specifically, the saturated fatty acid palmitate has pleiotropic effects on β-cell function and survival. The present study sought to determine the mechanism by which palmitate affects intracellular Ca²⁺ in pancr...
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| Language: | English |
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University of British Columbia
2009
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| Online Access: | http://hdl.handle.net/2429/12553 |