The role of SHIP in dendritic cell differentiation and function
SHIP (SH2-containing inositol 5'-phosphatase) is a hematopoietic restricted enzyme responsible for the hydrolysis of the phosphatidylinositol 3-kinase-generated second messenger PI-3,4,5-P₃ to PI-3,4-P₂ and, thereby, negatively regulates cell survival, proliferation and differentiation. Herein...
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| Format: | Others |
| Language: | English |
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University of British Columbia
2009
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| Online Access: | http://hdl.handle.net/2429/11079 |