Inhibition of UDP-glucose dehydrogenase by 6-Thiopurine and its oxidative metabolites: possible mechanism for its interaction within the bilirubin excretion pathway and 6-Thiopurine associated toxicity
Doctor of Philosophy === Department of Chemistry === Ryan Rafferty === 6-Thiopurine (6TP), or 6-mercaptopurine, is an actively prescribed drug in the treatment of acute lymphocytic leukemia since 1952. Although 6TP has beneficial and promising therapeutic uses, severe toxicities are associated with...
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| Language: | en |
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2018
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| Online Access: | http://hdl.handle.net/2097/38874 |