F-Actin regulation of SNARE-mediated insulin secretion

F-Actin regulation of SNARE-mediated insulin secretion

Indiana University-Purdue University Indianapolis (IUPUI) === In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane (PM) prevents insulin granule access...

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Bibliographic Details
Main Author: Kalwat, Michael Andrew
Other Authors: Thurmond, Debbie C.
Language:en_US
Published: 2013
Subjects:
F-actin
SNARE
Syntaxin
Gelsolin
PAK1
Cdc42
diabetes
insulin secretion
islet
ERK
Diabetes > Research
Diabetes > Pathophysiology
Pancreatic beta cells
Insulin > Physiological effect
Actin genes
Exocytosis
Glycoproteins
Membranes (Biology) > Research > Methodology
Synapses
Glucose
Cells > Mechanical properties
Cellular signal transduction > Research
Online Access:http://hdl.handle.net/1805/3624

Internet

http://hdl.handle.net/1805/3624

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