Structure and Function of the G Domain of Parkinson's Disease-Associated Protein LRRK2

Structure and Function of the G Domain of Parkinson's Disease-Associated Protein LRRK2

Indiana University-Purdue University Indianapolis (IUPUI) === Mutations in the gene encoding for leucine rich repeats kinase 2 (LRRK2) are commonly found in Parkinson’s disease. Recently, we found that the disease-associated point mutations at residue R1441 in the G domain (ROC) of LRRK2 resulted in...

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Bibliographic Details
Main Author: Wu, Chunxiang
Other Authors: Hoang, Quyen Q.
Language:en_US
Published: 2019
Subjects:
conformational dynamics
enzyme activation
GTPase
leucine rich repeat kinase 2
oligomeric states
Parkinson's disease
Online Access:http://hdl.handle.net/1805/20692

Internet

http://hdl.handle.net/1805/20692

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