Obstacles and Circumvention Strategies for Hematopoietic Stem Cell Transduction by Recombinant Adeno-associated Virus Vectors

Obstacles and Circumvention Strategies for Hematopoietic Stem Cell Transduction by Recombinant Adeno-associated Virus Vectors

Indiana University-Purdue University Indianapolis (IUPUI) === High-efficiency transduction of hematopoietic stem cells (HSCs) by recombinant adeno-associated virus serotype 2 (AAV2) vectors is limited by (i) inadequate expression of cellular receptor/co-receptors for AAV2; (ii) impaired intracellula...

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Bibliographic Details
Main Author: Maina, Caroline Njeri
Other Authors: Srivastava, Arun
Language:en_US
Published: 2009
Subjects:
Adeno-associated virus
AAV serotype
gene therapy
hematopoietic stem cells
sickle cell disease
Hematopoietic stem cells
Sickle cell anemia
Gene therapy
Online Access:http://hdl.handle.net/1805/1869

Internet

http://hdl.handle.net/1805/1869

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