Role of ATF4 in directing gene expression in the basal state and during the unfolded protein response in liver

Role of ATF4 in directing gene expression in the basal state and during the unfolded protein response in liver

Indiana University-Purdue University Indianapolis (IUPUI) === Disturbances in membrane composition and protein folding in the endoplasmic reticulum (ER) trigger the unfolded protein response (UPR). Three UPR sensory proteins, PERK (PEK/EIF2AK3), IRE1, and ATF6 are each activated by ER stress. PERK...

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Bibliographic Details
Main Author:	Fusakio, Michael Edward
Other Authors:	Wek, Ronald C.
Language:	en_US
Published:	2016
Subjects:	ATF4 Next generation sequencing Unfolded protein Cellular stress Endoplasmic reticulum Proteins Protein folding Cellular signal transduction Stress (physiology) Proteins > Synthesis Fatty liver Cholesterol Gene expression
Online Access:	http://hdl.handle.net/1805/11001

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