Pirin Allosterically Modulates The Dynamics And Interactions Of The κB DNA In The NF-κB Supramolecular Complex
The NF-κB family of transcription factors controls a number of essential cellular functions. Pirin is a non-heme iron (Fe) redox specific co-regulator of NF-κB (p65) and has been shown to modulate the affinity between the homodimeric p65 and the DNA. The allosteric effect of the active Fe(III) form...
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ScholarWorks @ Georgia State University
2017
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| Online Access: | http://scholarworks.gsu.edu/chemistry_theses/108 http://scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1109&context=chemistry_theses |