Molecular mechanisms of spermine on its synergistic effect with beta-lactams against Staphylococcus aureus
Spermine (Spm), a potent bactericidal polyamine, exerts a strong synergistic effect with β-lactams against methicillin-resistant Staphylococcus aureus (MRSA) in a pH-dependent manner. At high pH (>8) Spm is a potent nucleophile, and able to form Spm-β-lactam adduct. At physiological pH (or lower)...
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| Format: | Others |
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Digital Archive @ GSU
2012
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| Online Access: | http://digitalarchive.gsu.edu/biology_diss/121 http://digitalarchive.gsu.edu/cgi/viewcontent.cgi?article=1123&context=biology_diss |