Design and synthesis of small molecule inhibitors of zinc metalloenzymes

Design and synthesis of small molecule inhibitors of zinc metalloenzymes

Histone deacetylases (HDACs) are a class of enzymes that play a crucial role in DNA expression by removing an acetyl group from the ɛ-N-acetyl lysine residue on histone proteins. Out of 18 isoforms of HDAC enzymes which are classified into 4 classes, only 11 of them are metalloenzymes that require z...

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Bibliographic Details
Main Author: Patil, Vishal
Published: Georgia Institute of Technology 2013
Subjects:
Bifunctional inhibitors
Isoform selectivity
Spliceosome assembly inhibitors
Leishmania
Malaria
Histone deacetylase inhibitors
Cancer chemotherapy
Zinc binding groups
Metalloenzymes
Enzymes
Metalloproteins
Online Access:http://hdl.handle.net/1853/45859

Internet

http://hdl.handle.net/1853/45859

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