Broadening the enyzme-catalyzed synthesis of semi-synthetic antibiotics

Broadening the enyzme-catalyzed synthesis of semi-synthetic antibiotics

An alpha-amino ester hydrolase (AEH) applicable to synthesis of semi-synthetic antibiotics was cloned from the genomic DNA of Xanthomonas campestris pv. campestris sp. strain ATCC 33913. AEHs catalyze the synthesis and hydrolysis of alpha-amino beta-lactam antibiotics. The enzyme was characterized f...

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Bibliographic Details
Main Author:	Blum, Janna Karen
Published:	Georgia Institute of Technology 2011
Subjects:	Antibiotics Protein engineering Enzymes Biocatalyst Antibiotics Synthesis Beta lactamases Microbial enzymes
Online Access:	http://hdl.handle.net/1853/39528

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