Chromatin, SF-1, and CtBP structural and post-translational modifications induced by ACTH/cAMP accelerate CYP17 transcription rate
CYP17 is an ACTH/cAMP inducible gene in the human adrenal cortex encoding a cytochrome P450 enzyme with sterol 17α-hydroxylase activity and 17,20 lyase activity essential for biosynthesis of cortisol and androgens. Studies carried out during the past decade have shown that acclerated transcription o...
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Georgia Institute of Technology
2009
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| Online Access: | http://hdl.handle.net/1853/26595 |