Chromatin, SF-1, and CtBP structural and post-translational modifications induced by ACTH/cAMP accelerate CYP17 transcription rate

Chromatin, SF-1, and CtBP structural and post-translational modifications induced by ACTH/cAMP accelerate CYP17 transcription rate

CYP17 is an ACTH/cAMP inducible gene in the human adrenal cortex encoding a cytochrome P450 enzyme with sterol 17α-hydroxylase activity and 17,20 lyase activity essential for biosynthesis of cortisol and androgens. Studies carried out during the past decade have shown that acclerated transcription o...

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Bibliographic Details
Main Author: Dammer, Eric B.
Published: Georgia Institute of Technology 2009
Subjects:
Nuclear receptor ligand gating
Transcription cycles
Cyclic transcription
CAMP dependent transcription
Ligand accessibility model
PKA dependent pyridine nucleotide reduction
Adrenal cortex
Genetic transcription
Chromatin
Online Access:http://hdl.handle.net/1853/26595

Internet

http://hdl.handle.net/1853/26595

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