Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia

The current study analyzed the effects of environmental enrichment versus isolation housing on the behavioral sensitization to nicotine in the neonatal quinpirole (NQ; dopamine D2-like agonist) model of dopamine D2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats incr...

Full description

Bibliographic Details
Main Authors: Brown, Russell W., Schlitt, Marjorie A., Owens, Alex S., DePreter, Caitlynn C., Cummins, Elizabeth D., Kirby, Seth L., Gill, W. Drew, Burgess, Katherine C.
Published: Digital Commons @ East Tennessee State University 2018
Subjects:
Online Access:https://dc.etsu.edu/etsu-works/2767
https://doi.org/10.1159/000486391
id ndltd-ETSU-oai-dc.etsu.edu-etsu-works-3864
record_format oai_dc
spelling ndltd-ETSU-oai-dc.etsu.edu-etsu-works-38642019-05-16T05:06:46Z Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia Brown, Russell W. Schlitt, Marjorie A. Owens, Alex S. DePreter, Caitlynn C. Cummins, Elizabeth D. Kirby, Seth L. Gill, W. Drew Burgess, Katherine C. The current study analyzed the effects of environmental enrichment versus isolation housing on the behavioral sensitization to nicotine in the neonatal quinpirole (NQ; dopamine D2-like agonist) model of dopamine D2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D2 receptor sensitivity throughout the animal's lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS) from postnatal day (P)1 to P21, weaned, and immediately placed into enriched housing or isolated in wire cages throughout the experiment. Rats were behaviorally sensitized to nicotine (0.5 mg/kg base) or saline every consecutive day from P38 to P45, and brain tissue was harvested at P46. Results revealed that neither housing condition reduced nicotine sensitization in NQ rats, whereas enrichment reduced sensitization to nicotine in NS-treated animals. The nucleus accumbens (NAcc) was analyzed for glial cell line-derived neurotrophic factor (GDNF), a neurotrophin important in dopamine plasticity. Results were complex, and revealed that NAcc GDNF was increased in animals given nicotine, regardless of housing condition. Further, enrichment increased GDNF in NQ rats regardless of adolescent drug treatment and in NS-treated rats given nicotine, but did not increase GDNF in NS-treated controls compared to the isolated housing condition. This study demonstrates that environmental experience has a prominent impact on the behavioral and the neural plasticity NAcc response to nicotine in adolescence. 2018-01-01T08:00:00Z text https://dc.etsu.edu/etsu-works/2767 https://doi.org/10.1159/000486391 ETSU Faculty Works Digital Commons @ East Tennessee State University dopamine dopamine receptor developing brain animal model neurotrophic factor nucleus accumbens schizophrenia Biomedical Sciences Substance Abuse and Addiction
collection NDLTD
sources NDLTD
topic dopamine
dopamine receptor
developing brain
animal model
neurotrophic factor
nucleus accumbens
schizophrenia
Biomedical Sciences
Substance Abuse and Addiction
spellingShingle dopamine
dopamine receptor
developing brain
animal model
neurotrophic factor
nucleus accumbens
schizophrenia
Biomedical Sciences
Substance Abuse and Addiction
Brown, Russell W.
Schlitt, Marjorie A.
Owens, Alex S.
DePreter, Caitlynn C.
Cummins, Elizabeth D.
Kirby, Seth L.
Gill, W. Drew
Burgess, Katherine C.
Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia
description The current study analyzed the effects of environmental enrichment versus isolation housing on the behavioral sensitization to nicotine in the neonatal quinpirole (NQ; dopamine D2-like agonist) model of dopamine D2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D2 receptor sensitivity throughout the animal's lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS) from postnatal day (P)1 to P21, weaned, and immediately placed into enriched housing or isolated in wire cages throughout the experiment. Rats were behaviorally sensitized to nicotine (0.5 mg/kg base) or saline every consecutive day from P38 to P45, and brain tissue was harvested at P46. Results revealed that neither housing condition reduced nicotine sensitization in NQ rats, whereas enrichment reduced sensitization to nicotine in NS-treated animals. The nucleus accumbens (NAcc) was analyzed for glial cell line-derived neurotrophic factor (GDNF), a neurotrophin important in dopamine plasticity. Results were complex, and revealed that NAcc GDNF was increased in animals given nicotine, regardless of housing condition. Further, enrichment increased GDNF in NQ rats regardless of adolescent drug treatment and in NS-treated rats given nicotine, but did not increase GDNF in NS-treated controls compared to the isolated housing condition. This study demonstrates that environmental experience has a prominent impact on the behavioral and the neural plasticity NAcc response to nicotine in adolescence.
author Brown, Russell W.
Schlitt, Marjorie A.
Owens, Alex S.
DePreter, Caitlynn C.
Cummins, Elizabeth D.
Kirby, Seth L.
Gill, W. Drew
Burgess, Katherine C.
author_facet Brown, Russell W.
Schlitt, Marjorie A.
Owens, Alex S.
DePreter, Caitlynn C.
Cummins, Elizabeth D.
Kirby, Seth L.
Gill, W. Drew
Burgess, Katherine C.
author_sort Brown, Russell W.
title Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia
title_short Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia
title_full Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia
title_fullStr Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia
title_full_unstemmed Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia
title_sort effects of environmental enrichment on nicotine sensitization in rats neonatally treated with quinpirole: analyses of glial cell line-derived neurotrophic factor and implications towards schizophrenia
publisher Digital Commons @ East Tennessee State University
publishDate 2018
url https://dc.etsu.edu/etsu-works/2767
https://doi.org/10.1159/000486391
work_keys_str_mv AT brownrussellw effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
AT schlittmarjoriea effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
AT owensalexs effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
AT depretercaitlynnc effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
AT cumminselizabethd effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
AT kirbysethl effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
AT gillwdrew effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
AT burgesskatherinec effectsofenvironmentalenrichmentonnicotinesensitizationinratsneonatallytreatedwithquinpiroleanalysesofglialcelllinederivedneurotrophicfactorandimplicationstowardsschizophrenia
_version_ 1719189534275534848