Effects of Sarizotan in Animal Models of ADHD: Challenging Pharmacokinetic–Pharmacodynamic Relationships

Effects of Sarizotan in Animal Models of ADHD: Challenging Pharmacokinetic–Pharmacodynamic Relationships

Sarizotan 1-[(2R)-3,4-dihydro-2H-chromen-2-yl]-N-[[5-(4-fluorophenyl) pyridin-3-yl]methyl] methenamine, showed an in vivo pharmaco-EEG profile resembling that of methylphenidate which is used in attention deficit/hyperactivity disorder (ADHD). In turn, we tested sarizotan against impulsivity in juve...

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Bibliographic Details
Main Authors: Danysz, Wojciech, Flik, Gunnar, McCreary, Andrew, Tober, Carsten, Dimpfel, Wilfried, Bizot, Jean C., Kostrzewa, Richard, Brown, Russell W., Jatzke, Claudia C., Greco, Sergio, Jenssen, Ann-Kristin, Parsons, Christopher. G.
Published: Digital Commons @ East Tennessee State University 2015
Subjects:
5-HT1A
EEG
impulsivity
in vivo electrophysiology
microdialysis
receptor occupancy
Biomedical Sciences
Neurosciences
Online Access:https://dc.etsu.edu/etsu-works/948
https://doi.org/10.1007/s00702-015-1392-6

Internet

https://dc.etsu.edu/etsu-works/948
https://doi.org/10.1007/s00702-015-1392-6

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