Perinatal Treatments with the Dopamine D2-Receptor Agonist Quinpirole Produces Permanent D2-Receptor Supersensitization: A Model of Schizophrenia
Repeated daily treatments of perinatal rats with the dopamine D2-receptor (D2-R) agonist quinpirole for a week or more produces the phenomenon of ‘priming’—gradual but long-term sensitization of D2-R. In fact a daily dose of quinpirole as low as 50 µg/kg/day is adequate for sensitizing D2-R. Primed...
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Digital Commons @ East Tennessee State University
2016
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| Online Access: | https://dc.etsu.edu/etsu-works/945 https://doi.org/10.1007/s11064-015-1757-0 |