Synthesis, Characterization and Biological Evaluation of Novel (S,E)-11-[2-(Arylmethylene) Hydrazono] Pyrrolo [2,1-c] [1,4] Benzodiazepine Derivatives

Synthesis, Characterization and Biological Evaluation of Novel (S,E)-11-[2-(Arylmethylene) Hydrazono] Pyrrolo [2,1-c] [1,4] Benzodiazepine Derivatives

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Pyrrolo [2,1-c] [1,4] benzodiazepine (PBD) is a class of natural products obtained from various actinomycetes which have both anti-tumor and antibiotic activities and can bind to specific sequences of DNA. PBD-dilactam was initially produced using isatoic anhydride and (L)-proline which was then con...

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Bibliographic Details
Main Author: Mingle, David
Format: Others
Language:English
Published: Digital Commons @ East Tennessee State University 2019
Subjects:
: Pyrrolobenzodiazepine (PBD)
L-proline
isatoic anhydride
Lawesson’s reagent
cytotoxicity
cancer cell lines
non-β-lactam β-lactamase inhibitors
cannabinoid
Organic Chemistry
Online Access:https://dc.etsu.edu/etd/3596
https://dc.etsu.edu/cgi/viewcontent.cgi?article=5064&context=etd

Internet

https://dc.etsu.edu/etd/3596
https://dc.etsu.edu/cgi/viewcontent.cgi?article=5064&context=etd

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