Molecular Docking, Synthesis and Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepines Derivatives as Non-β-lactam β-lactamases Inhibitors

Molecular Docking, Synthesis and Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepines Derivatives as Non-β-lactam β-lactamases Inhibitors

Our research aim was to design, synthesize, and study the competitive enzyme inhibition kinetics of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives as potential non-²-lactam ²-lactamase inhibitors. All compounds (1-13) passed the Lipinski’s rule of 5 test and were docked into the active site of...

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Bibliographic Details
Main Author:	Osazee, Joseph Osamudiamen
Format:	Others
Language:	English
Published:	Digital Commons @ East Tennessee State University 2016
Subjects:	Antibiotic resistance β-Lactamases inhibitors Pyrrolo[2 1-c][1 4]benzodiazepines Lipinski's rule Molecular docking Enzyme kinetics Chemistry
Online Access:	https://dc.etsu.edu/etd/3082 https://dc.etsu.edu/cgi/viewcontent.cgi?article=4486&context=etd

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