Molecular Docking, Synthesis and Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepines Derivatives as Non-β-lactam β-lactamases Inhibitors
Our research aim was to design, synthesize, and study the competitive enzyme inhibition kinetics of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives as potential non-²-lactam ²-lactamase inhibitors. All compounds (1-13) passed the Lipinski’s rule of 5 test and were docked into the active site of...
| Main Author: | |
|---|---|
| Format: | Others |
| Language: | English |
| Published: |
Digital Commons @ East Tennessee State University
2016
|
| Subjects: | |
| Online Access: | https://dc.etsu.edu/etd/3082 https://dc.etsu.edu/cgi/viewcontent.cgi?article=4486&context=etd |