The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion

<p>As members of the adaptive immune response, T- and B- cells express unique antigen receptors generated from antigen receptor loci. These loci encode multiple Variable (V), Diversity (D), and Joining (J) gene segments. Through a process known as V(D)J recombination, genomic rearrangements...

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Bibliographic Details
Main Author: Kondilis-Mangum, Hrisavgi Demetrios
Other Authors: Krangel, Michael S
Published: 2011
Subjects:
Online Access:http://hdl.handle.net/10161/3912