Critical evaluation of P2X7 receptor antagonists in selected seizure models

Critical evaluation of P2X7 receptor antagonists in selected seizure models

The ATP-gated P2X7 receptor (P2X7R) is a non-selective cation channel which senses high extracellular ATP concentrations and has been suggested as a target for the treatment of neuroinflammation and neurodegenerative diseases. The use of P2X7R antagonists may therefore be a viable approach for treat...

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Bibliographic Details
Main Authors: Fischer, Wolfgang, Franke, Heike, Krügel, Ute, Müller, Heiko, Dinkel, Klaus, Lord, Brian, Letavic, Michael A., Henshall, David C., Engel, Tobias
Other Authors: Universität Leipzig, Medizinische Fakultät
Format: Article
Language:English
Published: Universitätsbibliothek Leipzig 2016
Subjects:
tonisch-klonischer Anfall
Immunfluoreszenz
krampflösende Mittel
Epilepsie
tonic-clonic seizure
Immunofluorescence
anticonvulsants
epilepsy
ddc:610
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206115
http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206115
http://www.qucosa.de/fileadmin/data/qucosa/documents/20611/OAP-2016-098_Fischer_journal.pone.0156468.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206115
http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206115
http://www.qucosa.de/fileadmin/data/qucosa/documents/20611/OAP-2016-098_Fischer_journal.pone.0156468.pdf

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