Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs
Background: Medulloblastoma (MB) is the most common pediatric brain tumor. Current treatment regimes consisting of primary surgery followed by radio- and chemotherapy, achieve 5-year overall survival rates of only about 60 %. Therapy-induced endocrine and neurocognitive deficits are common late adve...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Universitätsbibliothek Leipzig
2016
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| Subjects: | |
| Online Access: | http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205276 http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205276 http://www.qucosa.de/fileadmin/data/qucosa/documents/20527/OAP-2016-067_patties_art_10.1186_s13046-016-0376-1.pdf |