Impact of Myeloperoxidase-derived oxidants on the product profile of human 5-Lipoxygenase

Impact of Myeloperoxidase-derived oxidants on the product profile of human 5-Lipoxygenase

Human 5-lipoxygenase (5-LOX) oxidizes arachidonic acid to 5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HpETE) and leukotriene (LT) A4. In neutrophils, LTA4 is further converted to the potent chemoattractant LTB4. These cells also contain the heme enzyme myeloperoxidase (MPO), which produces...

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Bibliographic Details
Main Authors: Zschaler, Josefin, Dorow, Juliane, Schöpe, Louisa, Ceglarek, Uta, Arnhold, Jürgen
Other Authors: Universität Leipzig, Institut für Medizinische Physik und Biophysik
Format: Article
Language:English
Published: Universitätsbibliothek Leipzig 2016
Subjects:
Eicosanoid
Arachidonsäure
HCIO
hypobromige Säure
Neutrophile
freie Radikale
eicosanoids
arachidonic acid
HOCl
HOBr
neutrophils
free radicals
ddc:570
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-201824
http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-201824
http://www.qucosa.de/fileadmin/data/qucosa/documents/20182/Zschaler%20et%20al%202015_Free%20Radic%20Biol%20Med.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-201824
http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-201824
http://www.qucosa.de/fileadmin/data/qucosa/documents/20182/Zschaler%20et%20al%202015_Free%20Radic%20Biol%20Med.pdf

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