From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns

From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns

Drug repositioning identifies new indications for known drugs. Here we report repositioning of the malaria drug amodiaquine as a potential anti-cancer agent. While most repositioning efforts emerge through serendipity, we have devised a computational approach, which exploits interaction patterns sha...

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Bibliographic Details
Main Authors: Salentin, Sebastian, Adasme, Melissa F., Heinrich, Jörg C., Haupt, V. Joachim, Daminelli, Simone, Zhang, Yixin, Schroeder, Michael
Other Authors: Nature Publishing Group,
Format: Article
Language:English
Published: Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2017
Subjects:
Computational Biologie und Bioinformatik
Virtual Screening
Technische Universität Dresden
Publikationsfond
Computational biology and bioinformatics
Virtual screening
technische Universität Dresden
Publishing Fund
ddc:520
rvk:UA 1000
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230907
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230907
http://www.qucosa.de/fileadmin/data/qucosa/documents/23090/s41598-017-11924-4.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230907
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230907
http://www.qucosa.de/fileadmin/data/qucosa/documents/23090/s41598-017-11924-4.pdf

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