Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2

Elevated levels of circulating asymmetric and symmetric dimethylarginines (ADMA and SDMA) predict and potentially contribute to end organ damage in cardiovascular diseases. Alanine-glyoxylate aminotransferase 2 (AGXT2) regulates systemic levels of ADMA and SDMA, and also of beta-aminoisobutyric acid...

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Bibliographic Details
Main Authors:	Burdin, Dmitry V., Kolobov, Alexey A., Brocker, Chad, Soshnev, Alexey A., Samusik, Nikolay, Demyanov, Anton v., Brilloff, Silke, Jarzebska, Natalia, Martens-Lobenhoffer, Jens, Mieth, Maren, Maas, Renke, Bornstein, Stefan R., Bode-Böger, Stefanie M., Gonzalez, Frank, Weiss, Norbert, Rodionov, Roman N.
Other Authors:	Nature Publishing Group,
Format:	Article
Language:	English
Published:	Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2017
Subjects:	Kardiovaskuläre Genetik Genregulation Hypertonie Prognostische Marker Transkriptionselemente Technische Universität Dresden Publikationsfonds Cardiovascular genetics Gene regulation Hypertension Publishing Fund Prognostic markers Transcriptional regulatory elements
Online Access:	http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226882 http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226882 http://www.qucosa.de/fileadmin/data/qucosa/documents/22688/srep35503.pdf