Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2

Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2

Elevated levels of circulating asymmetric and symmetric dimethylarginines (ADMA and SDMA) predict and potentially contribute to end organ damage in cardiovascular diseases. Alanine-glyoxylate aminotransferase 2 (AGXT2) regulates systemic levels of ADMA and SDMA, and also of beta-aminoisobutyric acid...

Full description

Bibliographic Details
Main Authors: Burdin, Dmitry V., Kolobov, Alexey A., Brocker, Chad, Soshnev, Alexey A., Samusik, Nikolay, Demyanov, Anton v., Brilloff, Silke, Jarzebska, Natalia, Martens-Lobenhoffer, Jens, Mieth, Maren, Maas, Renke, Bornstein, Stefan R., Bode-Böger, Stefanie M., Gonzalez, Frank, Weiss, Norbert, Rodionov, Roman N.
Other Authors: Nature Publishing Group,
Format: Article
Language:English
Published: Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2017
Subjects:
Kardiovaskuläre Genetik
Genregulation
Hypertonie Prognostische Marker Transkriptionselemente
Technische Universität Dresden
Publikationsfonds
Cardiovascular genetics
Gene regulation
Hypertension
Publishing Fund Prognostic markers
Transcriptional regulatory elements
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226882
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226882
http://www.qucosa.de/fileadmin/data/qucosa/documents/22688/srep35503.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226882
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226882
http://www.qucosa.de/fileadmin/data/qucosa/documents/22688/srep35503.pdf

Similar Items