A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

DNA repair is essential to maintain genome integrity, and genes with roles in DNA repair are frequently mutated in a variety of human diseases. Repair via homologous recombination typically restores the original DNA sequence without introducing mutations, and a number of genes that are required for...

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Bibliographic Details
Main Authors: Buchholz, Frank, Słabicki, Mikołaj, Theis, Mirko, Krastev, Dragomir B., Samsonov, Sergey, Mundwiller, Emeline, Junqueira, Magno, Paszkowski-Rogacz, Maciej, Teyra, Joan, Heninger, Anne-Kristin, Poser, Ina, Prieur, Fabienne, Truchetto, Jérémy, Confavreux, Christian, Marelli, Cécilia, Durr, Alexandra, Camdessanche, Jean Philippe, Brice, Alexis, Shevchenko, Andrej, Pisabarro, M. Teresa, Stevanin, Giovanni
Other Authors: Public Library of Science,
Format: Article
Language:English
Published: Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2015
Subjects:
DNA
Neurologie
ddc:570
ddc:610
rvk:XA 10000
rvk:WA 15000
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-180795
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-180795
http://www.qucosa.de/fileadmin/data/qucosa/documents/18079/journal.pbio.1000408.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-180795
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-180795
http://www.qucosa.de/fileadmin/data/qucosa/documents/18079/journal.pbio.1000408.pdf

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