Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)
The assessment of teratogenic effects of chemicals is generally performed using in vivo teratogenicity assays e.g., in rats or rabbits. Following the 3R principles, the development of alternative methods is encouraged to reduce the number of animal tests. From this perspective, we have developed an...
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| Format: | Doctoral Thesis |
| Language: | English |
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Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden
2008
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| Online Access: | http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848 http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848 http://www.qucosa.de/fileadmin/data/qucosa/documents/354/1228302283465-6084.pdf |