Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)

Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)

The assessment of teratogenic effects of chemicals is generally performed using in vivo teratogenicity assays e.g., in rats or rabbits. Following the 3R principles, the development of alternative methods is encouraged to reduce the number of animal tests. From this perspective, we have developed an...

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Bibliographic Details
Main Author: Busquet, François
Other Authors: Technische Universität Dresden, Fakultät Forst-, Geo- und Hydrowissenschaften
Format: Doctoral Thesis
Language:English
Published: Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2008
Subjects:
zebrafish
cyclophosphamide
ethanol
alternatives to animal testing
teratogenicity
metabolic activation
Alternative zum Tierversuch
Teratogenität
Aktivierung System
ddc:520
rvk:WI 4400
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848
http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848
http://www.qucosa.de/fileadmin/data/qucosa/documents/354/1228302283465-6084.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848
http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848
http://www.qucosa.de/fileadmin/data/qucosa/documents/354/1228302283465-6084.pdf

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