N-terminal isoforms of the p53 tumour suppressor protein : effects on p53 transcriptional activity and expression in cutaneous melanoma
The p53 tumour suppressor protein has a highly complex pattern of regulation at transcriptional and posttranslationallevels. The discovery of p53 isoforms has added another layer of complexity to the mechanisms thatregulate p53 functions. Indeed, p53 is expressed as 12 isoforms that differ in their...
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| Language: | English |
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Université Claude Bernard - Lyon I
2012
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00995000 http://tel.archives-ouvertes.fr/docs/00/99/50/00/PDF/TH2012Hafsi_Hind.pdf |