Adaptation of dosing regimen of chemotherapies based on pharmacodynamic models

Adaptation of dosing regimen of chemotherapies based on pharmacodynamic models

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There is high variability in response to cancer chemotherapies among patients. Its sources are diverse: genetic, physiologic, comorbidities, concomitant medications, environment, compliance, etc. As the therapeutic window of anticancer drugs is usually narrow, such variability may have serious conse...

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Bibliographic Details
Main Author: Paule, Inès
Language:ENG
Published: Université Claude Bernard - Lyon I 2011
Subjects:
[SDV:MHEP] Life Sciences/Human health and pathology
Dosing individualization
Mixed-effects pharmacokinetic and pharmacodynamic models
Discrete data models
Empirical Bayes estimates
Capecitabine
Hand-foot syndrome
Hydroxyurea
Sickle cell anemia
Online Access:http://tel.archives-ouvertes.fr/tel-00846454
http://tel.archives-ouvertes.fr/docs/00/84/64/54/PDF/TH2011_Paule_Ines.pdf

Internet

http://tel.archives-ouvertes.fr/tel-00846454
http://tel.archives-ouvertes.fr/docs/00/84/64/54/PDF/TH2011_Paule_Ines.pdf

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