Compréhension de l'énantiosélectivité de la lipase B de Candida antarctica : étude par modélisation moléculaire et expérimentation

Compréhension de l'énantiosélectivité de la lipase B de Candida antarctica : étude par modélisation moléculaire et expérimentation

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La lipase B de Candida antarctica (CALB) est un enzyme présentant des propriétés énantiosélectives très intéressantes pour l'obtention de molécules énantio pures par dédoublement cinétique de mélanges racémiques,molécules utilisées comme synthons dans l'industrie pharmaceutique. En effet,...

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Bibliographic Details
Main Author:	Chaput, Ludovic
Language:	FRE
Published:	Université de La Rochelle 2012
Subjects:	[SDV:SA] Life Sciences/Agricultural sciences Lipase B de Candida antarctica Énantiosélectivité Biocatalyse Modélisation moléculaire Intermédiaire tétraédrique Perturbation de l'énergie libre Effet d'empreinte Mutant T42V S47A T42V/S47A
Online Access:	http://tel.archives-ouvertes.fr/tel-00825876 http://tel.archives-ouvertes.fr/docs/00/82/58/76/PDF/2012Chaput30539.pdf

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