Determination of the secondary structure of minus strong-stop DNA and the mechanism of annealing involved in the first strand transfer in HIV-1
The 1st strand transfer, a crucial step of reverse transcription involving the HIV-1 nucleocapsid protein (NC), relies on base pairing of the r sequence of strong-stop DNA (ssDNA) with the 3' R sequence of viral RNA (3' UTR) which forms the TAR and polyA stem-loops. The r sequence can form...
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| Language: | ENG |
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École normale supérieure de Cachan - ENS Cachan
2012
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00777238 http://tel.archives-ouvertes.fr/docs/00/77/72/38/PDF/Chen2012.pdf |