Determination of the secondary structure of minus strong-stop DNA and the mechanism of annealing involved in the first strand transfer in HIV-1

Determination of the secondary structure of minus strong-stop DNA and the mechanism of annealing involved in the first strand transfer in HIV-1

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The 1st strand transfer, a crucial step of reverse transcription involving the HIV-1 nucleocapsid protein (NC), relies on base pairing of the r sequence of strong-stop DNA (ssDNA) with the 3' R sequence of viral RNA (3' UTR) which forms the TAR and polyA stem-loops. The r sequence can form...

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Bibliographic Details
Main Author: Chen, Yingying
Language:ENG
Published: École normale supérieure de Cachan - ENS Cachan 2012
Subjects:
[SDV:SA] Life Sciences/Agricultural sciences
[SDV:SA] Sciences du Vivant/Sciences agricoles
Strong-stop DNA
First strand transfer
Hiv-1
Reverse transcription
HIV-1 nucleocapsid protein
Online Access:http://tel.archives-ouvertes.fr/tel-00777238
http://tel.archives-ouvertes.fr/docs/00/77/72/38/PDF/Chen2012.pdf

Internet

http://tel.archives-ouvertes.fr/tel-00777238
http://tel.archives-ouvertes.fr/docs/00/77/72/38/PDF/Chen2012.pdf

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