Synthesis of an α,3-Dehydrotoluene Biradical Precursor with DNA Cleaving Activity and Studies Directed Toward the Total Synthesis of Tetracycline
<p>The synthesis and characterization of a model of the enediyne antibiotics is described. The prepared conjugate consists of an α,3-dehydrotoluene biradical precursor tethered to an N-methylpyrrolecarboxamide minor groove binding element. The conjugate is shown to bind and cleave DNA with...