Synthesis of an α,3-Dehydrotoluene Biradical Precursor with DNA Cleaving Activity and Studies Directed Toward the Total Synthesis of Tetracycline

Synthesis of an α,3-Dehydrotoluene Biradical Precursor with DNA Cleaving Activity and Studies Directed Toward the Total Synthesis of Tetracycline

<p>The synthesis and characterization of a model of the enediyne antibiotics is described. The prepared conjugate consists of an α,3-dehydrotoluene biradical precursor tethered to an N-methylpyrrolecarboxamide minor groove binding element. The conjugate is shown to bind and cleave DNA with...

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Bibliographic Details
Main Author: Parrish, Cynthia Ann
Format: Others
Language:en
Published: 1999
Online Access:https://thesis.library.caltech.edu/9922/2/Parrish_ca_1999.pdf
Parrish, Cynthia Ann (1999) Synthesis of an α,3-Dehydrotoluene Biradical Precursor with DNA Cleaving Activity and Studies Directed Toward the Total Synthesis of Tetracycline. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3m0y-w259. https://resolver.caltech.edu/CaltechTHESIS:09122016-085802807 <https://resolver.caltech.edu/CaltechTHESIS:09122016-085802807>

Internet

https://thesis.library.caltech.edu/9922/2/Parrish_ca_1999.pdf
Parrish, Cynthia Ann (1999) Synthesis of an α,3-Dehydrotoluene Biradical Precursor with DNA Cleaving Activity and Studies Directed Toward the Total Synthesis of Tetracycline. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3m0y-w259. https://resolver.caltech.edu/CaltechTHESIS:09122016-085802807 <https://resolver.caltech.edu/CaltechTHESIS:09122016-085802807>

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