Targeting DNA Repeat Sequences with Py-Im Polyamides
Hairpin pyrrole-imdazole polyamides are cell-permeable, sequence-programmable oligomers that bind in the minor groove of DNA. This thesis describes studies of Py-Im polyamides targeted to biologically important DNA repeat sequences for the purpose of modulating disease states. Design of a hairpin po...
Internet
https://thesis.library.caltech.edu/8812/31/JSK_Thesis_Full.pdfhttps://thesis.library.caltech.edu/8812/25/JSK_Thesis_TOC_Ch1.pdf
https://thesis.library.caltech.edu/8812/10/JSK_Thesis_Ch2_Methylation.pdf
https://thesis.library.caltech.edu/8812/19/JSK_Thesis_Ch3_immunogenicity.pdf
https://thesis.library.caltech.edu/8812/1/JSK_Thesis_Ch4_DM1.pdf
https://thesis.library.caltech.edu/8812/7/JSK_Thesis_Ch5_HIF-ChIPseq.pdf
Kang, JeenJoo Sophia (2015) Targeting DNA Repeat Sequences with Py-Im Polyamides. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z93R0QSQ. https://resolver.caltech.edu/CaltechTHESIS:04052015-200117829 <https://resolver.caltech.edu/CaltechTHESIS:04052015-200117829>