Biophysics of V(D)J Recombination and Genome Packaging: In Singulo Studies on RAG, HMGB1, and TFAM
The recombination-activating gene products, RAG1 and RAG2, initiate V(D)J recombination during lymphocyte development by cleaving DNA adjacent to conserved recombination signal sequences (RSSs). The reaction involves DNA binding, synapsis, and cleavage at two RSSs located on the same DNA molecule an...
Internet
https://thesis.library.caltech.edu/8504/7/Geoff%20Lovely%20Thesis-12-19-14.pdfLovely, Geoffrey A. (2014) Biophysics of V(D)J Recombination and Genome Packaging: In Singulo Studies on RAG, HMGB1, and TFAM. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9W9573H. https://resolver.caltech.edu/CaltechTHESIS:06072014-140700155 <https://resolver.caltech.edu/CaltechTHESIS:06072014-140700155>