Sterochemically modified polyamides for recognition in the minor groove of DNA
The design of synthetic molecules that recognize specific sequences of DNA is an ongoing challenge in molecular medicine. Cell-permeable small molecules targeting predetermined DNA sequences offer a potential approach for offsetting the abnormal effects of misregulated gene-expression. Over the p...
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https://thesis.library.caltech.edu/8130/7/Herman%202001.pdfHerman, David Matthew (2001) Sterochemically modified polyamides for recognition in the minor groove of DNA. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/vsf2-fe75. https://resolver.caltech.edu/CaltechTHESIS:03122014-104807866 <https://resolver.caltech.edu/CaltechTHESIS:03122014-104807866>