Misfolding Dominates Protein Evolution
The diverse array of protein functions depends upon these molecules' reliable ability to fold into the native structures determined by their amino-acid sequences. Because mutations that alter a protein's sequence frequently disrupt its folding, protein evolution explores protein sequence...
Internet
https://thesis.library.caltech.edu/2404/1/drummond-thesis.pdfDrummond, David Allan (2006) Misfolding Dominates Protein Evolution. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/DH8E-2N10. https://resolver.caltech.edu/CaltechETD:etd-06022006-154329 <https://resolver.caltech.edu/CaltechETD:etd-06022006-154329>