Exploring the Proteome: Insights into Eukaryotic Protein Synthesis Using Puromycin Analogs
Puromycin is a protein synthesis inhibitor that acts as a structural analog of an aminoacyl-tRNA. The ribosome mistakenly inserts puromycin in place of aminoacyl-tRNA resulting in truncated proteins containing the drug at their C-terminus. Herein, the puromycin reaction is re-examined in a cell-fr...
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https://thesis.library.caltech.edu/2355/11/Entire_Thesis.pdfhttps://thesis.library.caltech.edu/2355/12/Title.pdf
https://thesis.library.caltech.edu/2355/2/Acknowledgements.pdf
https://thesis.library.caltech.edu/2355/1/Abstract.pdf
https://thesis.library.caltech.edu/2355/10/Contents.pdf
https://thesis.library.caltech.edu/2355/3/Chapter_1.pdf
https://thesis.library.caltech.edu/2355/4/Chapter_2.pdf
https://thesis.library.caltech.edu/2355/5/Chapter_3.pdf
https://thesis.library.caltech.edu/2355/6/Chapter_4.pdf
https://thesis.library.caltech.edu/2355/7/Chapter_5.pdf
https://thesis.library.caltech.edu/2355/8/Chapter_6.pdf
https://thesis.library.caltech.edu/2355/9/Chapter_7.pdf
Starck, Shelley Ruth (2004) Exploring the Proteome: Insights into Eukaryotic Protein Synthesis Using Puromycin Analogs. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/WKXS-KM18. https://resolver.caltech.edu/CaltechETD:etd-06012004-235945 <https://resolver.caltech.edu/CaltechETD:etd-06012004-235945>