The Organization and Expression of the Human Dihydrofolate Reductase Gene in Methotrexate-Resistant and Methotrexate-Sensitive Cell Lines

The Organization and Expression of the Human Dihydrofolate Reductase Gene in Methotrexate-Resistant and Methotrexate-Sensitive Cell Lines

<p>The analysis of several derivatives of the human cell lines HeLa and VA<sub>2</sub>-B, selected for resistance to methotrexate (MTX), shows a striking variability in the dihydrofolate reductase (DHFR) enzyme levels, chromosome constitution and growth characteristics in the absen...

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Bibliographic Details
Main Author: Masters, Jeffrey Nelson
Format: Others
Language:en
Published: 1985
Online Access:https://thesis.library.caltech.edu/11372/2/Masters_JN_1985.pdf
Masters, Jeffrey Nelson (1985) The Organization and Expression of the Human Dihydrofolate Reductase Gene in Methotrexate-Resistant and Methotrexate-Sensitive Cell Lines. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/jaa8-jx74. https://resolver.caltech.edu/CaltechTHESIS:01312019-142248860 <https://resolver.caltech.edu/CaltechTHESIS:01312019-142248860>

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https://thesis.library.caltech.edu/11372/2/Masters_JN_1985.pdf
Masters, Jeffrey Nelson (1985) The Organization and Expression of the Human Dihydrofolate Reductase Gene in Methotrexate-Resistant and Methotrexate-Sensitive Cell Lines. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/jaa8-jx74. https://resolver.caltech.edu/CaltechTHESIS:01312019-142248860 <https://resolver.caltech.edu/CaltechTHESIS:01312019-142248860>

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