An integrative bioinformatics approach for analyses of multi-level transcriptional regulation and three-dimensional organization in the epidermis and skin appendages. Exploring genomic transcriptional profiles of the distinct stages of hair follicle and sweat gland development and analyses of mechanism integrating the transcriptional regulation, linear and high-order genome organization within epidermal differentiation complex in keratinocytes.

The transcription in the eukaryotic cells involves epigenetic regulatory mechanisms that control local and higher-order chromatin remodelling. In the skin, keratinocyte-specific genes are organized into distinct loci including Epidermal Differentiation Complex (EDC) and Keratin type I/II loci. Th...

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Bibliographic Details

Main Author:	Poterlowicz, Krzysztof
Other Authors:	Botchkarev, Vladimir A.
Language:	en
Published:	University of Bradford 2013
Subjects:	Bioinformatics Microarray ChIP-on-chip Chromosome conformation capture carbon copy Chromosome conformation capture carbon copy (5c) Transcriptional regulation Three-dimensional genome organization Hair follicle Sweat gland Keratinocytes
Online Access:	http://hdl.handle.net/10454/5658