Detergent addition to trypsin digest and Ion Mobility Separation prior to MS/MS improves peptide yield and Protein Identification for in situ Proteomic Investigation of Frozen and FFPE Adenocarcinoma tissue sections.

Detergent addition to trypsin digest and Ion Mobility Separation prior to MS/MS improves peptide yield and Protein Identification for in situ Proteomic Investigation of Frozen and FFPE Adenocarcinoma tissue sections.

no === The identification of proteins involved in tumour progression or which permit enhanced or novel therapeutic targeting is essential for cancer research. Direct MALDI analysis of tissue sections is rapidly demonstrating its potential for protein imaging and profiling in the investigation of a r...

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Bibliographic Details
Main Authors: Djidja, M-C., Francese, S., Loadman, Paul M., Sutton, Chris W., Scriven, P., Claude, E., Snel, M.F., Franck, J., Salzet, M., Clench, M.R.
Language:en
Published: Wiley 2010
Subjects:
Ion Mobility
Adenocarcinoma
Formalin fixed paraffin embedded
Imaging
MALDI
MCF7
Stress proteins
Cancer investigation
Tumour xenograft
Protein identification
Online Access:http://hdl.handle.net/10454/4565

Internet

http://hdl.handle.net/10454/4565

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