Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension

Yes === Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculat...

Full description

Bibliographic Details
Main Authors:	Sharmin, Nahid, Nganwuchu, Chinyere C., Nasim, Md. Talat
Language:	en
Published:	2021
Subjects:	Pulmonary arterial hypertension TGF-β BMP Pulmonary vasculature ALK5 inhibitor
Online Access:	http://hdl.handle.net/10454/18507

id	ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-18507
record_format	oai_dc
spelling	ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-185072021-07-23T05:01:07Z Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension Sharmin, Nahid Nganwuchu, Chinyere C. Nasim, Md. Talat Pulmonary arterial hypertension TGF-β BMP Pulmonary vasculature ALK5 inhibitor Yes Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches. Research carried out at Nasim laboratories is funded by GrowMedtech, the Royal Society, the Commonwealth Scholarship Commission (CSC) and the University of Bradford (UoB). N.S. is funded by the CSC and C.C.N. is partly funded by the UoB. The full-text of this article will be released for public view at the end of the publisher embargo on 06 May 2022. 2021-05-23T23:05:48Z 2021-06-07T15:10:56Z 2021-05-23T23:05:48Z 2021-06-07T15:10:56Z 2021-07 2021-04-07 2021-05-06 2022-05-06 2021-05-23T22:05:59Z Article Accepted manuscript Sharmin N, Nganwuchu CC and Nasim Md T (2021) Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension. Trends in Pharmacological Sciences. 42(7): 510-513. http://hdl.handle.net/10454/18507 en https://doi.org/10.1016/j.tips.2021.04.002 © 2021 Elsevier Ltd. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
collection	NDLTD
language	en
sources	NDLTD
topic	Pulmonary arterial hypertension TGF-β BMP Pulmonary vasculature ALK5 inhibitor
spellingShingle	Pulmonary arterial hypertension TGF-β BMP Pulmonary vasculature ALK5 inhibitor Sharmin, Nahid Nganwuchu, Chinyere C. Nasim, Md. Talat Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
description	Yes === Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches. === Research carried out at Nasim laboratories is funded by GrowMedtech, the Royal Society, the Commonwealth Scholarship Commission (CSC) and the University of Bradford (UoB). N.S. is funded by the CSC and C.C.N. is partly funded by the UoB. === The full-text of this article will be released for public view at the end of the publisher embargo on 06 May 2022.
author	Sharmin, Nahid Nganwuchu, Chinyere C. Nasim, Md. Talat
author_facet	Sharmin, Nahid Nganwuchu, Chinyere C. Nasim, Md. Talat
author_sort	Sharmin, Nahid
title	Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
title_short	Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
title_full	Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
title_fullStr	Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
title_full_unstemmed	Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
title_sort	targeting the tgf-β signaling pathway for resolution of pulmonary arterial hypertension
publishDate	2021
url	http://hdl.handle.net/10454/18507
work_keys_str_mv	AT sharminnahid targetingthetgfbsignalingpathwayforresolutionofpulmonaryarterialhypertension AT nganwuchuchinyerec targetingthetgfbsignalingpathwayforresolutionofpulmonaryarterialhypertension AT nasimmdtalat targetingthetgfbsignalingpathwayforresolutionofpulmonaryarterialhypertension
_version_	1719417212434907136

Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension

Similar Items